Journal Articles

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* Corresponding author. Peer-reviewed journal articles are listed newest first. Preprints are listed separately.

Bage S, Yadav A, Gaur K, Gahlot K, Purva M, Saini M, Dadarwal S, Gehlot P, Kumari S, Bhutra S, Sawant DM, Brünnert D, Kasliwal N, Goyal P*

Identification of STK35L1 as a potential prognostic biomarker in breast carcinoma, and its expression exhibits high correlation with EGFR activity Functional & Integrative Genomics, 2026 26(1)

DOI: 10.1007/s10142-026-02021-9

Malik S, De I, Yadav A, Poonia V, Gaur K, Goyal P, Singh M, Yadav J

Inhibition of Aβ(40) peptide aggregation by Milk-derived Amyloid-like Protein Aggregates (MAPA) Biological Chemistry, 2026 1–10

DOI: 10.1515/hsz-2025-0208

Jain V, Bage S, Dhiman N, Singh S, Yadav A, Brünnert D, Sawant DM, Goyal P*

Relevance of EGFR-HER2 Dual Inhibition in Breast Cancer Targets, 2026 4(1):10

DOI: 10.3390/targets4010010

Yadav A, Sharma PK, Hazarika M, Gehlot P, Bage S, Saini M, Gaur K, Aswathi AP, Thakur M, Sawant DM, Singh AP, Brünnert D, Goyal P*

Differential Expression of STK35L1-Associated Transcription Factors in Plasmodium Infection During the Liver Stage of Malaria Kinases and Phosphatases, 2025 3(4):26

DOI: 10.3390/kinasesphosphatases3040026

Rajan M, Sivanesan S, Ramachandran K, Goyal P, Palanivelu P, Ghosh A, Vijayaraghavan R, Vasavan SS

TUDCA combined with Syndopa protects the midbrain and gut from MPTP toxicity in a Parkinson’s disease mouse model: Immunohistochemical evidence Biomolecules and Biomedicine, 2025 25(12):2776–2788

DOI: 10.17305/bb.2025.12519

Yadav A, Gaur K, Sharma PK, Gehlot P, Bage S, Saini M, Brünnert D, Goyal P*

The Multifaceted Role of STK35/STK35L1 in Human Diseases: A Time for Critical Appraisal Kinases and Phosphatases, 2025 3(2):12

DOI: 10.3390/kinasesphosphatases3020012

Sivanesan S, Howell MD, Kaushik V, Jayakumar R, Pari M, Goyal P*

Multifunctional Tasks and an Energy Crisis are Crucial Players in Determining the Vulnerability of the Entorhinal Cortex to Early Damage in Alzheimer's Disease Current Alzheimer Research, 2024 21(5):295–311

DOI: 10.2174/0115672050324909240823104209

Manjunath GK, Sharma S, Nashier D, Vasanthaiah S, Jha S, Bage S, Mitra T, Goyal P, Neerathilingam M, Kumar A

Breast cancer genomic analyses reveal genes, mutations, and signaling networks Functional & Integrative Genomics, 2024 24(6):206

DOI: 10.1007/s10142-024-01484-y

Gehlot P, Brünnert D, Kaushik V, Yadav A, Bage S, Gaur K, Saini M, Ehrhardt J, Manjunath GK, Kumar A, Kasliwal N, Sharma AK, Zygmunt M, Goyal P*

Unconventional localization of PAI-1 in PML bodies: A possible link with cellular growth of endothelial cells Biochemistry and Biophysics Reports, 2024 39:101793

DOI: 10.1016/j.bbrep.2024.101793

Brünnert D, Seupel R, Goyal P, Bach M, Schraud H, Kirner S, Köster E, Feineis D, Bargou RC, Schlosser A, Bringmann G, Chatterjee M

Ancistrocladinium A Induces Apoptosis in Proteasome Inhibitor-Resistant Multiple Myeloma Cells: A Promising Therapeutic Agent Candidate Pharmaceuticals, 2023 16(8):1181

DOI: 10.3390/ph16081181

Verma N, Srivastava S, Malik R, Goyal P, Pandey J

Inhibition and disintegration of Bacillus subtilis biofilm with small molecule inhibitors identified through virtual screening for targeting TasA(28–261), the major protein component of ECM Journal of Biomolecular Structure and Dynamics, 2023 41(6):2431–2447

DOI: 10.1080/07391102.2022.2033135

Uttarilli A, Amalakanti S, Kommoju PR, Sharma S, Goyal P, Manjunath GK, Upadhayay V, Parveen A, Tandon R, Prasad KS, Dakal TC, Ben Shlomo I, Yousef M, Neerathilingam M, Kumar A

Super-rapid race for saving lives by developing COVID-19 vaccines Journal of Integrative Bioinformatics, 2021 18(1):27–43

DOI: 10.1515/jib-2021-0002

Brünnert D, Kumar V, Kaushik V, Ehrhardt J, Chahar KR, Sharma PK, Zygmunt M, Goyal P*

Thrombin impairs the angiogenic activity of extravillous trophoblast cells via monocyte chemotactic protein-1 (MCP-1): A possible link with preeclampsia Reproductive Biology, 2021 21(3):100516

DOI: 10.1016/j.repbio.2021.100516

Kaushik V, Brünnert D, Hanschmann EM, Sharma PK, Anand BG, Kar K, Kateriya S, Goyal P*

The intrinsic amyloidogenic propensity of cofilin-1 is aggravated by Cys-80 oxidation: A possible link with neurodegenerative diseases Biochemical and Biophysical Research Communications, 2021 569:187–192

DOI: 10.1016/j.bbrc.2021.07.013

Chahar KR, Kumar V, Sharma PK, Brünnert D, Kaushik V, Gehlot P, Shekhawat I, Kumar S, Sharma AK, Kumari S, Goyal P*

Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1-phosphate in extravillous trophoblasts Reproductive Medicine and Biology, 2021 20(3):267–276

DOI: 10.1002/rmb2.12379

Sharma PK, Kalia I, Kaushik V, Brünnert D, Quadiri A, Kashif M, Chahar KR, Agrawal A, Singh AP, Goyal P*

STK35L1 regulates host cell cycle-related genes and is essential for Plasmodium infection during the liver stage of malaria Experimental Cell Research, 2021 406(2):112764

DOI: 10.1016/j.yexcr.2021.112764

Gudipati PK, Biswas S, Goyal P

Anti Hepatitis C viral drugs Remdesivir and Uprifosbuvir derivatives are better inhibitors of SARS Cov2 RNA-dependent RNA polymerase determined by docking International Journal of Engineering Applied Sciences and Technology, 2020 5(3):474–481

DOI: 10.33564/IJEAST.2020.v05i03.076

Verma N, Srivastava S, Malik R, Yadav JK, Goyal P, Pandey J

Computational investigation for modeling the protein-protein interaction of TasA(28–261)-TapA(33–253): a decisive process in biofilm formation by Bacillus subtilis Journal of Molecular Modeling, 2020 26(9):226

DOI: 10.1007/s00894-020-04507-0

Brünnert D, Kraus M, Stühmer T, Kirner S, Heiden R, Goyal P, Driessen C, Bargou RC, Chatterjee M

Novel cell line models to study mechanisms and overcoming strategies of proteasome inhibitor resistance in multiple myeloma Biochimica et Biophysica Acta – Molecular Basis of Disease, 2019 1865(6):1666–1676

DOI: 10.1016/j.bbadis.2019.04.003

Brünnert D, Shekhawat I, Chahar KR, Ehrhardt J, Pandey J, Yadav JK, Zygmunt M, Goyal P*

Thrombin stimulates gene expression and secretion of IL-11 via protease-activated receptor-1 and regulates extravillous trophoblast cell migration Journal of Reproductive Immunology, 2019 132:35–41

DOI: 10.1016/j.jri.2019.03.001

Kumar V, Gour S, Verma A, Suman K, Gadhave K, Mishra PM, Goyal P, Pandey J, Giri R, Yadav JK

The mechanism of phosphatidylcholine-induced interference of PAP (248–286) aggregation Journal of Peptide Science, 2019 25(4):e3152

DOI: 10.1002/psc.3152

Gour S, Kumar V, Singh A, Gadhave K, Goyal P, Pandey J, Giri R, Yadav JK

Mammalian antimicrobial peptide protegrin-4 self assembles and forms amyloid-like aggregates: Assessment of its functional relevance Journal of Peptide Science, 2019 25(3):e3151

DOI: 10.1002/psc.3151

Kumar V, Gour S, Peter OS, Gandhi S, Goyal P, Pandey J, Harsholia RS, Yadav JK

Effect of green tea polyphenol epigallocatechin-3-gallate on the aggregation of αA(66–80) peptide, a major fragment of αA-crystallin involved in cataract development Current Eye Research, 2017 42(10):1368–1377

DOI: 10.1080/02713683.2017.1324628

Verma N, Rai AK, Kaushik V, Brünnert D, Chahar KR, Pandey J, Goyal P*

Identification of gefitinib off-targets using a structure-based systems biology approach; their validation with reverse docking and retrospective data mining Scientific Reports, 2016 6:33949

DOI: 10.1038/srep33949

Brünnert D, Piccenini S, Ehrhardt J, Zygmunt M, Goyal P*

Sphingosine 1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8/SVneo cells Placenta, 2015 36(10):1115–1121

DOI: 10.1016/j.placenta.2015.08.010

Jamasbi J, Megens RTA, Bianchini M, Münch G, Ungerer M, Faussner A, Sherman S, Walker A, Goyal P, Jung S, Brandl R, Weber C, Lorenz R, Farndale R, Elia N, Siess W

Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies Journal of the American College of Cardiology, 2015 65(22):2404–2415

DOI: 10.1016/j.jacc.2015.03.573

Brünnert D, Sztachelska M, Bornkessel F, Treder N, Wolczynski S, Goyal P*, Zygmunt M

Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells Molecular Human Reproduction, 2014 20(10):1016–1025

DOI: 10.1093/molehr/gau051

Herr F, Horndasch M, Howe D, Baal N, Goyal P, Fischer S, Zygmunt M, Preissner KT

Human placenta-derived Wnt-5a induces the expression of ICAM-1 and VCAM-1 in CD133(+)CD34(+)-hematopoietic progenitor cells Reproductive Biology, 2014 14(4):262–275

DOI: 10.1016/j.repbio.2014.08.001

Koensgen D, Bruennert D, Ungureanu S, Sofroni D, Braicu EI, Sehouli J, Sümnig A, Delogu S, Zygmunt M, Goyal P, Evert M, Olek S, Biebler KE, Mustea A

Polymorphism of the IL-8 gene and the risk of ovarian cancer Cytokine, 2015 71(2):334–338

DOI: 10.1016/j.cyto.2014.07.254

Goyal P*, Pandey D, Brünnert D, Hammer E, Zygmunt M, Siess W

Cofilin oligomer formation occurs in vivo and is regulated by cofilin phosphorylation PLoS ONE, 2013 8(8):e71769

DOI: 10.1371/journal.pone.0071769

Goyal P, Brünnert D, Ehrhardt J, Bredow M, Piccenini S, Zygmunt M

Cytokine IL-6 secretion by trophoblasts regulated via Sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways Molecular Human Reproduction, 2013 19(8):528–538

DOI: 10.1093/molehr/gat023

Kumar A, Bhandari A, Sinha R, Sardar P, Sushma M, Goyal P, Goswami C, Grapputo A

Molecular Phylogeny of OVOL Genes Illustrates a Conserved C2H2 Zinc Finger Domain Coupled by Hypervariable Unstructured Regions PLoS ONE, 2012 7(6):e39399

DOI: 10.1371/journal.pone.0039399

Djafarzadeh R, Sauter M, Notohamiprodjo S, Noessner E, Goyal P, Siess W, Wörnle M, Ribeiro A, Himmelein S, Sitter S, Nelson PJ

Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells PLoS ONE, 2012 7(4):e33963

DOI: 10.1371/journal.pone.0033963

Kumar A, Bhandari A, Sinha R, Goyal P, Grapputo A

Spliceosomal intron insertions in genome compacted ray-finned fishes as evident from phylogeny of MC receptors, also supported by a few other GPCRs PLoS ONE, 2011 6(8):e22046

DOI: 10.1371/journal.pone.0022046

Goyal P*, Behring A, Kumar A, Siess W

STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells PLoS ONE, 2011 6(1):e16249

DOI: 10.1371/journal.pone.0016249

Goyal P*, Behring A, Kumar A, Siess W

Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates PLoS ONE, 2009 4(9):e6981

DOI: 10.1371/journal.pone.0006981

Williams JR, Khandoga AL, Goyal P, Fells JI, Perygin DH, Siess W, Parrill AL, Tigyi G, Fujiwara Y

Unique Ligand Selectivity of the GPR92/LPA5 Lysophosphatidate Receptor Indicates Role in Human Platelet Activation Journal of Biological Chemistry, 2009 284(25):17304–17319

DOI: 10.1074/jbc.M109.003194

Pandey D, Goyal P, Dwivedi S, Siess W

Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets Blood, 2009 114(2):415–424

DOI: 10.1182/blood-2008-10-183582

Khandoga AL, Fujiwara Y, Goyal P, Pandey D, Tsukahara R, Bolen A, Guo H, Wilke N, Liu J, Valentine WJ, Durgam GG, Miller DD, Jiang G, Prestwich GD, Tigyi G, Siess W

Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin Platelets, 2008 19(6):415–427

DOI: 10.1080/09537100802220468

Tyagi NK, Kumar A, Goyal P, Pandey D, Siess W, Kinne RKH

D-Glucose-recognition and phlorizin-binding sites in human sodium/D-glucose cotransporter 1 (hSGLT1): a tryptophan scanning study Biochemistry, 2007 46(47):13616–13628

DOI: 10.1021/bi701193x

Pandey D, Goyal P, Siess W

Lysophosphatidic acid stimulation of platelets rapidly induces Ca2+-dependent dephosphorylation of cofilin that is independent of dense granule secretion and aggregation Blood Cells, Molecules, and Diseases, 2007 38(3):269–279

DOI: 10.1016/j.bcmd.2007.01.002

Kumar A, Tyagi NK, Goyal P, Pandey D, Siess W, Kinne RKH

Sodium-independent low-affinity D-glucose transport by human sodium/D-glucose cotransporter 1: critical role of tryptophan 561 Biochemistry, 2007 46(10):2758–2766

DOI: 10.1021/bi061696x

Pandey D, Goyal P, Bamburg JR, Siess W

Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets Blood, 2006 107(2):575–583

DOI: 10.1182/blood-2004-11-4377

Massberg S, Konrad I, Schürzinger K, Lorenz M, Schneider S, Zohlnhoefer D, Hoppe K, Schiemann M, Kennerknecht E, Sauer S, Schulz C, Kerstan S, Rudelius M, Seidl S, Sorge F, Langer H, Peluso M, Goyal P, Vestweber D, Emambokus NR, Busch DH, Frampton J, Gawaz M

Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo Journal of Experimental Medicine, 2006 203(5):1221–1233

DOI: 10.1084/jem.20051772

Goyal P*, Pandey D, Siess W

Phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells Journal of Biological Chemistry, 2006 281(35):25223–25230

DOI: 10.1074/jbc.M603399200

Daub K, Langer H, Seizer P, Stellos K, May AE, Goyal P, Bigalke B, Schönberger T, Geisler T, Siegel-Axel D, Oostendorp RA, Lindemann S, Gawaz M

Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells FASEB Journal, 2006 20(14):2559–2561

DOI: 10.1096/fj.06-6265fje

Tyagi NK, Goyal P, Kumar A, Pandey D, Siess W, Kinne RKH

High-yield functional expression of human sodium/d-glucose cotransporter1 in Pichia pastoris and characterization of ligand-induced conformational changes as studied by tryptophan fluorescence Biochemistry, 2005 44(47):15514–15524

DOI: 10.1021/bi051377q

Penz S, Reininger AJ, Brandl R, Goyal P, Rabie T, Bernlochner I, Rother E, Goetz C, Engelmann B, Smethurst PA, Ouwehand WH, Farndale R, Nieswandt B, Siess W

Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI FASEB Journal, 2005 19(8):898–909

DOI: 10.1096/fj.04-2748com

Miehe U, Neumaier-Wagner P, Kadyrov M, Goyal P, Alfer J, Rath W, Huppertz B

Concerted upregulation of CLP36 and smooth muscle actin protein expression in human endometrium during decidualization Cells Tissues Organs, 2005 179(3):109–114

DOI: 10.1159/000085002

Goyal P, Pandey D, Behring A, Siess W

Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283 Journal of Biological Chemistry, 2005 280(30):27569–27577

DOI: 10.1074/jbc.M504448200

Rother E, Brandl R, Baker DL, Goyal P, Gebhard H, Tigyi G, Siess W

Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques Circulation, 2003 108(6):741–747

DOI: 10.1161/01.CIR.0000083715.37658.C4

Kaushik V, Hanschmann EM, Brünnert D, Kumari P, Anand BG, Sharma PK, Kar K, Goyal P*

Computational and biochemical analyses reveal that cofilin-2 self assembles into amyloid-like structures and promotes the aggregation of other proteinaceous species: Pathogenic relevance to myopathies bioRxiv, 2021 2021.11.27.470221 (preprint; not peer reviewed)

DOI: 10.1101/2021.11.27.470221

Kumar A, Parveen A, Kumar N, Bairy S, Kaushik V, Chandola C, Sharma J, Sharma PK, Agarwal A, Pandey A, Goyal P, Neerathilingam M

Characterization of Nucleocapsid (N) Protein from Novel Coronavirus SARS-CoV-2 Preprints.org, 2020 2020050413 (preprint; not peer reviewed)

DOI: 10.20944/preprints202005.0413.v1

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Invited Talk: Deciphering the Multifaceted Roles of the STK35 Family