STK35/STK35L1 Biology
Investigating the structure, regulation, cellular functions, and disease relevance of the STK35/STK35L1 kinase family.
PDIK1L and Cancer Signaling
Defining PDIK1L biology in breast cancer and its relationship with EGFR/HER2-associated adaptive transcriptional responses.
Structural and Computational Biology
Using sequence analysis, structural modeling, and molecular dynamics to investigate kinase conformation, regulation, and catalytic mechanisms.
Disease Signaling and Molecular Medicine
Studying signaling mechanisms in cancer, neurodegeneration, cellular stress, and host–pathogen interactions.
About the Goyal Lab
The Goyal Lab investigates cell signaling and molecular medicine, with particular emphasis on poorly characterized protein kinases and disease-relevant signaling networks. Our research integrates molecular and cellular biology with structural, computational, and disease-oriented approaches to understand how signaling proteins regulate cellular behavior and contribute to human disease. Current areas include STK35/STK35L1, PDIK1L and EGFR/HER2-associated signaling, cofilin biology and protein aggregation, PAI-1 signaling, host–pathogen interactions, and related questions in molecular medicine.
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Our research has evolved from the molecular identification and characterization of signaling proteins toward increasingly integrated questions in cell biology and disease. Studies of STK35/STK35L1 progressed from kinase identity and evolutionary relationships to nuclear actin, cell-cycle regulation, cell migration, host–pathogen interactions, structural regulation, and cancer biology. This progression now provides the foundation for broader investigations into kinase signaling, disease mechanisms, and molecular medicine.
Latest Event
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Invited Talk: Deciphering the Multifaceted Roles of the STK35 Family
September 12, 2026
50+
PEER-REVIEWED PUBLICATIONS
20+
YEARS IN MOLECULAR MEDICINE RESEARCH
15+
YEARS OF PG & PhD TEACHING / SUPERVISION
Selected Publications & Research Output
The Goyal Lab has published across protein kinase biology, cell signaling, cancer biology, host–pathogen interactions, cytoskeletal regulation, and molecular medicine. Recent work extends our long-standing STK35/STK35L1 program into breast cancer and disease signaling.
- Identification of STK35L1 as a potential prognostic biomarker in breast carcinoma, and its expression exhibits high correlation with EGFR activity. Functional & Integrative Genomics (2026).
- Differential Expression of STK35L1-Associated Transcription Factors in Plasmodium Infection During the Liver Stage of Malaria. Kinases and Phosphatases (2025).
- STK35L1 regulates Plasmodium infection and expression of cell cycle genes during the liver stage of malaria. Experimental Cell Research (2021).
