Molecular mechanisms of cell signaling in health and diseases.
Cell signaling is a complex process of communication that is essential for basic cellular activities and coordinating cell functions in a tissue or an organ. A cell constantly comprehends the surrounding microenvironment, process the received-signals and responds to them precisely. This is the basics of cell communication during development, tissue repair, defense against foreign invasion and crucial for normal tissue homeostasis. Glitches in cellular signals processing are the basis of diseases such as cancer, cardiovascular diseases, neuronal disorders, autoimmunity, and diabetes. A better understanding of molecular mechanism underlying cell signaling during physiological and pathophysiological processes could lead to develop novel therapeutic strategies.
The major focus of this lab is to understand the cell signaling pathways through which the different cell functions are regulated and how these functions are perturbed under different disease conditions such as preeclampsia, atherosclerosis and tumor progression. Major research themes include GPCR signaling in the regulation of cytoskeleton dynamics, secretion of cytokines, cell migration and proliferation, cell cycle, and regulation of gene expression.
My Group focuses on the following projects