Cellular Signaling and Human Diseases
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I received my Ph.D from the Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilian University, Munich in Germany and completed postdoc from the same Institute. 


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Our publications in refereed journals

Links to the full text articles can be found  via NCBI or please Contact us

Verma N, Rai AK, Kaushik V, Brünnert D, Chahar KR, Brünnert D, Pandey J, Goyal P* (2016) Identification of gefitinib off-targets using a structure-based systems biology approach; their validation with reverse docking and retrospective data mining. Sci Rep Sep 22;6:33949. doi: 10.1038/srep33949. (* Corresponding author)

Brünnert D, Piccenini S, Ehrhardt J, Zygmunt M, Goyal P* (2015) Sphingosine 1-phosphate regulates IL-8 expression and secretion via S1PR and S1PR receptors-mediated signaling in extravillous trophoblast derived HTR-8/SVneo cells. Placenta in press. (* Corresponding author)

Jamasbi J, Megens RTA, Bianchini M, Münch G, Ungerer M, Faussner A, Sherman S, Walker A, Goyal P, Jung S, Brandl R, Weber C, Lorenz R, Farndale R, Elia N, Siess W, (2015) Differential inhibition of human atherosclerotic plaque- induced platelet activation by dimeric GPVI-Fc and anti-GPVI antibodies: functional and imaging studies. JACC  65(22):2404-2415.

Brünnert D, Sztachelska M, Bornkessel F, Treder N, Wolczynski S, Goyal P*, Zygmunt M, (2014) Lysophosphatidic acid and Sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. Mol Hum Reprod  20(10):1016-1025.  (* Corresponding author)  

Herr F, Horndasch M, Howe D, Baal N, Goyal P, Fischer S, Zygmunt M, Preissner KT (2014) Human placenta-derived Wnt-5a induces the expression of ICAM-1 and VAM-1 in CD133+-hematopoietic progenitor cells. Reprod Biol 14(4):262-275.

Koensgen D, Bruennert D, Ungureanu S, Sofroni D, Braicu EI, Sehouli J, Sümnig A, Delogu S, Zygmunt M, Goyal P, Evert M, Olek S, Biebler KE, Mustea A, (2014) Polymorphism of the IL-8 gene and the risk of ovarian cancer. Cytokine 71(2):334-338.

Goyal P*, Pandey D, Brünnert D, Hammer E, Zygmunt M, Siess W (2013) Cofilin oligomer formation occurs in vivo and is regulated by cofilin phosphorylation. PLoS ONE  8(8):e71769. (* Corresponding author) 

Goyal P, Brünnert D, Ehrhardt J, Bredow M, Piccenini S, Zygmunt M, (2013) Cytokine IL-6 secretion by trophoblasts regulated via Sphingosine1phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways. Mol Hum Reprod  19(8):528538.  

Abhishek K, Bhandari A, Sinha R, Sardar S, Miss Sushma, Goyal P, Goswami C Grapputo A (2012) Molecular Phylogeny of OVOL Genes Illustrates a Conserved C2H2 Zinc Finger Domain Coupled by Hypervariable Unstructured Regions. PLoS ONE 7(6): e39399. 

Djafarzadeh R, Sauter M, Notohamiprodjo S, Noessner E, Goyal P, Siess W¸ Wörnle M, Ribeiro A, Himmelein S, Sitter S, Nelson PJ (2012) Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. PLoS ONE 7 (4): e33963.

Abhishek K, Bhandari A, Sinha R, Goyal P, Grapputo A (2011) Insights into spliceosomal introns insertions in genome compacted ray-finned fishes as evident from molecular phylogeny of melanocortin receptors. PLoS ONE 6 (8): e22046.  

Goyal P*, Behring A, Kumar A, Siess W (2011) STK35L1 Associates with Nuclear Actin and Regulates Cell Cycle and Migration of Endothelial Cells. PLoS ONE 6(1): e16249. (* Corresponding author) 

Goyal P*, Behring A, Kumar A, Siess W (2009) Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. PLoS ONE 4: e6981. (* Corresponding author)  

Williams JR, Khandoga AL, Goyal P, Fells JI, Perygin DH, Siess W, Parrill AL, Tigyi G, Fujiwara Y (2009) Unique Ligand Selectivity of the GPR92/LPA5 Lysophosphatidate Receptor Indicates Role in Human Platelet Activation. J Biol Chem 284: 17304-17319.  

Pandey D, Goyal P, Dwivedi S, Siess, W. (2009) Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin stimulated Platelets. Blood. 114: 415-24.  

Khandoga AL, Fujiwara Y, Goyal P, Pandey D, Tsukahara R, Bolen A, Guo H, Wilke N, Liu J, Valentine WJ, Durgam GG, Miller DD, Jiang G, Prestwich GD, Tigyi G, Siess W. (2008) Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets 19: 415-427.  

Tyagi NK, Kumar A, Goyal P, Pandey D, Siess W, Kinne RK (2007) D-Glucoserecognition and phlorizin-binding sites in human sodium/D-glucose cotransporter 1 (hSGLT1): a tryptophan scanning study. Biochemistry 46: 13616-13628. 

Pandey DGoyal P, Siess W (2007) Lysophosphatidic acid stimulation of platelets rapidly induces Ca2+-dependent dephosphorylation of cofilin that is independent of dense granule secretion and aggregation. Blood Cells Mol Dis 38: 269-279. 

Kumar A, Tyagi NK, Goyal P, Pandey D, Siess W, Kinne RK (2007) Sodiumindependent low-affinity D-glucose transport by human sodium/D-glucose cotransporter 1: critical role of tryptophan 561. Biochemistry 46: 2758-2766. 

Pandey DGoyal P, Bamburg JR, Siess W (2006) Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets. Blood 107: 575-583.

Massberg S, Konrad I, Schurzinger K, Lorenz M, Schneider S, Zohlnhoefer D, Hoppe K, Schiemann M, Kennerknecht E, Sauer S, Schulz C, Kerstan S, Rudelius M, Seidl S, Sorge F, Langer H, Peluso M, Goyal P, Vestweber D, Emambokus NR, Busch DH, Frampton J, Gawaz M (2006) Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med 203: 1221-1233. 

Goyal P*, Pandey D, Siess W (2006) Phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells. J Biol Chem 281: 25223-25230. (* Corresponding author) 

Daub K, Langer H, Seizer P, Stellos K, May AE, Goyal P, Bigalke B, Schonberger T, Geisler T, Siegel-Axel D, Oostendorp RA, Lindemann S, Gawaz M (2006) Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells. FASEB J 20: 2559-2561. I

Tyagi NK, Goyal P, Kumar A, Pandey D, Siess W, Kinne RK (2005) High-yield functional expression of human sodium/d-glucose cotransporter1 in Pichia pastoris and characterization of ligand-induced conformational changes as studied by tryptophan fluorescence. Biochemistry 44: 15514-15524. 

Penz S, Reininger AJ, Brandl R, Goyal P, Rabie T, Bernlochner I, Rother E, Goetz C, Engelmann B, Smethurst PA, Ouwehand WH, Farndale R, Nieswandt B, Siess W (2005) Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI. FASEB J 19: 898-909. 

Miehe U, Neumaier-Wagner P, Kadyrov M, Goyal P, Alfer J, Rath W, Huppertz B (2005) Concerted upregulation of CLP36 and smooth muscle actin protein expression in human endometrium during decidualization. Cells Tissues Organs 179: 109-114. 

Goyal P, Pandey D, Behring A, Siess W (2005) Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283. J Biol Chem 280: 27569-27577.

Rother, E., Brandl, R., Baker, D. L., Goyal, P., Gebhard, H., Tigyi, G., and Siess, W (2003) Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques. Circulation 108: 741-747.